HyperRef Clinical

HyperRef Clinical is a fast, offline antihypertensive drug reference built for hospital clinicians — emergency physicians, registrars, and pharmacists. 30 antihypertensive agents across 10 drug classes with full clinical profiles including adult, renal and hepatic dosing, mechanism with trial evidence (HOPE, LIFE, ASCOT, PARADIGM-HF, PATHWAY-2), indications, side effects by severity, drug interactions graded major/moderate/minor, and monitoring parameters. HYPERTENSIVE CRISIS — immediate-access IV protocols: Labetalol, GTN, Nitroprusside, Phentolamine. Scenario-specific guidance for aortic dissection, eclampsia, encephalopathy, ischaemic stroke, phaeochromocytoma. NICE NG136 + ESC/ESH 2023 treatment ladder Steps 1–4, resistant hypertension pathway, and special populations: pregnancy, CKD, diabetes, HFrEF, post-stroke, elderly, ethnic considerations. CLINICAL TOOLS — dose calculator with eGFR-based renal adjustment and drug interaction checker. 100% offline. No login. No data collected. This app is intended for educational, informational and reference purposes for healthcare professionals. It does not replace clinical judgment, professional medical advice, or local guidelines. All treatment decisions must be made by qualified healthcare professionals based on individual patient circumstances. Always verify against local formulary and local guidelines. It is not a substitute for professional clinical judgment, local guidelines, or specialist advice. Always follow institutional protocols and consult appropriate medical professionals when making treatment decisions. Dr Atif Elnil MBBS MRCP UK Neurology Department St George's Hospital London